Rosenblum-Vos L S, Meltzer S J, Leana-Cox J, Schwartz S
Department of Obstetrics/Gynecology, University of Maryland School of Medicine, Baltimore 21201.
Cancer Genet Cytogenet. 1993 Oct 15;70(2):127-31. doi: 10.1016/0165-4608(93)90182-l.
Cytogenetic analysis was performed on primary cultures of 21 squamous cell carcinomas of the esophagus (SCCE). Seven cases exhibited mosaic clonal chromosome abnormalities distributed as follows: two contained tetraploid cell populations, one with t(3;7)(p21;q11); two showed loss of the Y chromosome, one with double minutes; single cases demonstrated der(11)t(4;11)(q?27;q23); add(1)(p35) and del(4)(p12); and del(7)(p13), del(7)(q22q34), and der(11)t(7;11)(p?15;p?13). The remaining 14 cases had apparently normal karyotypes, possibly derived from stromal elements. These results demonstrate numerical abnormalities and the multiple occurrence of rearrangements involving chromosomes 7 and 11 in SCCE.
对21例食管鳞状细胞癌（SCCE）的原代培养物进行了细胞遗传学分析。7例呈现嵌合克隆染色体异常，分布如下：2例含有四倍体细胞群，其中1例伴有t(3;7)(p21;q11)；2例显示Y染色体缺失，其中1例伴有双微体；单例表现为der(11)t(4;11)(q?27;q23)、add(1)(p35)和del(4)(p12)；以及del(7)(p13)、del(7)(q22q34)和der(11)t(7;11)(p?15;p?13)。其余14例核型明显正常，可能源自基质成分。这些结果表明食管鳞状细胞癌存在数量异常以及涉及7号和11号染色体的重排多次出现。
