Del Forno C, Cerimele D, Serri F
Arch Dermatol Res. 1978 Aug 28;262(3):311-21. doi: 10.1007/BF00447367.
30 cases of initial psoriasis were studied. Pinhead-sized lesions, recently appeared, were excised and studied with histochemical methods for acid mucopolysaccharides. In all specimens a well defined reduction of the material stained with colloidal iron, with alcian blue with critical electrolyte concentrations and with toluidine blue was observed in the upper dermis, in particular in the papillary dermis in the center of the lesions, in correspondence of the squirting papillae. The more evident reduction of the staining with alcian blue with 0.1 M and 0.2 M MgCl2 suggests that the changes of the dermal ground substance are predominantly due to an alteration of the hyaluronic acid.
对30例初发性银屑病患者进行了研究。切除新近出现的针头大小的皮损，采用组织化学方法检测酸性黏多糖。在所有标本中，均观察到真皮上层，尤其是皮损中央乳头层真皮中与喷射状乳头相对应处，用胶体铁、临界电解质浓度的阿尔辛蓝和甲苯胺蓝染色的物质明显减少。用0.1M和0.2M氯化镁的阿尔辛蓝染色减少更为明显，提示真皮基质的变化主要是由于透明质酸的改变。
