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肿瘤独特型疫苗。VIII. 对长期存活的荷瘤小鼠血清及杂交瘤中保护性独特型的分析。

Tumor idiotype vaccines. VIII. Analysis of protective idiotype in sera and hybridomas derived from tumor-bearing mice with long-term survival.

作者信息

Chen J J, Kohler H

机构信息

San Diego Regional Cancer Center, CA 92121.

出版信息

Cancer Immunol Immunother. 1993 Nov;37(6):373-7. doi: 10.1007/BF01526793.

DOI:10.1007/BF01526793

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038383/

Abstract

In this study, the contribution of idiotype-positive antitumor antibodies (anti-Id) in protective tumor immunity was investigated. We have previously shown that among various anti-Id generated and typed as the internal-image Ab2 of the tumor-associated antibody (TAA) gp52, only 2F10 antibody induces protective immunity. Increase of the 2F10 idiotope in sera of tumor-bearing mice correlated with long-term survival, while in mice with short survival the circulating 2F10 idiotype decreased. 2F10+ Ig were purified from sera of tumor-bearing mice with long-term survival and the amount of 2F10+ anti-TAA antibodies was determined. Only about 3% of 2F10+ antibodies are 2F10+ anti-TAA+. Hybridomas were generated from a 2F10 high mouse with spontaneous tumor regression. Only 2 out of 52 tumor-specific hybridomas were 2F10+. These results suggest that the protective effect induced by 2F10 vaccination may not be directly mediated by 2F10+ antibodies but indirectly through the stimulation of a 2F10-specific cellular immune response.

摘要

在本研究中，研究了独特型阳性抗肿瘤抗体（抗独特型抗体）在保护性肿瘤免疫中的作用。我们之前已经表明，在产生并分型为肿瘤相关抗体（TAA）gp52的内影像Ab2的各种抗独特型抗体中，只有2F10抗体诱导保护性免疫。荷瘤小鼠血清中2F10独特型表位的增加与长期存活相关，而在存活期短的小鼠中，循环2F10独特型减少。从长期存活的荷瘤小鼠血清中纯化2F10+Ig，并测定2F10+抗TAA抗体的量。只有约3%的2F10+抗体是2F10+抗TAA+。从一只2F10高表达且肿瘤自发消退的小鼠中产生杂交瘤。52个肿瘤特异性杂交瘤中只有2个是2F10+。这些结果表明，2F10疫苗接种诱导的保护作用可能不是由2F10+抗体直接介导的，而是通过刺激2F10特异性细胞免疫反应间接介导的。