Zhang D H, Gu Y T, Pan W S
Zhong Shan Hospital, Shanghai Medical University.
Zhonghua Jie He He Hu Xi Za Zhi. 1993 Jun;16(3):150-3, 187.
19 patients suspected pleural mesothelioma were performed thoracoscopy. The overall diagnostic rate was 94.7% (18/19 cases). The macroscopic findings of 18 cases presented solitary, well circumscribed, smooth, rounded masses in 2 localized cases and multiple, clear, yellowish-white and "grape-like" granulations or malignant pleural thickening in 16 diffuse cases. Biopsy was taken in 18 cases under direct vision. The histological diagnosis showed 2 benign fibromatous mesothelioma and 16 malignant mesothelioma. Pleural mesothelioma was easily misdiagnosed as primary lung cancer, tuberculous pleurisy and metastatic pleural tumor. The diagnostic accuracy by cytological study of pleural effusions and needle biopsy of pleura both were low. Thoracoscopy is currently a suitable diagnostic method for pleural mesothelioma. The resection was considered as a proper treatment of choice for localized pleural mesothelioma. We recommend that thoracoscopic talc poudrage followed by chemotherapy on diffuse malignant mesothelioma with pleural effusion could be used to improve the survival rate and to prevent the recurrent effusion.
对19例疑似胸膜间皮瘤患者进行了胸腔镜检查。总体诊断率为94.7%(18/19例)。18例的宏观表现为:2例局限性病例中可见孤立的、边界清楚、表面光滑、圆形的肿块,16例弥漫性病例中可见多发的、清晰的、黄白色的“葡萄样”颗粒或恶性胸膜增厚。18例在直视下进行了活检。组织学诊断显示2例为良性纤维瘤性间皮瘤,16例为恶性间皮瘤。胸膜间皮瘤容易误诊为原发性肺癌、结核性胸膜炎和转移性胸膜肿瘤。胸腔积液细胞学检查和胸膜针吸活检的诊断准确性均较低。胸腔镜检查目前是胸膜间皮瘤合适的诊断方法。对于局限性胸膜间皮瘤,手术切除被认为是合适的治疗选择。我们建议,对于伴有胸腔积液的弥漫性恶性间皮瘤,胸腔镜滑石粉喷洒后联合化疗可用于提高生存率并防止胸腔积液复发。