早期帕金森病中泌汗功能障碍的评估

Assessment of sudomotor dysfunction in early Parkinson's disease.

作者信息

Kihara M, Kihara Y, Tukamoto T, Nishimura Y, Watanabe H, Hanakago R, Takahashi A

机构信息

Department of Internal Medicine, Daini Hospital, Tokyo Women's Medical College, Japan.

出版信息

Eur Neurol. 1993;33(5):363-5. doi: 10.1159/000116972.

DOI:10.1159/000116972

PMID:8243511

Abstract

We performed a quantitative sudomotor function test on 10 patients with early Parkinson's disease (PD) and 11 age-matched control subjects. Thermal warming increased the sweat rate in both PD and controls. There was no difference in sweat rate between the forearm and the thigh in either PD or controls. In PD, thyrotropin-releasing hormone (TRH) did not increase the sweat rate, whereas it did so in the controls. These results suggest that sudomotor dysfunction in early PD is minor but that there may be an impairment of TRH-induced sympathetic response in the early stages of PD.

摘要

我们对10例早期帕金森病（PD）患者和11名年龄匹配的对照受试者进行了定量汗腺功能测试。热刺激使PD患者和对照受试者的出汗率均增加。PD患者和对照受试者的前臂和大腿出汗率均无差异。在PD患者中，促甲状腺激素释放激素（TRH）并未增加出汗率，而在对照受试者中则增加了出汗率。这些结果表明，早期PD中的汗腺功能障碍较轻，但在PD早期可能存在TRH诱导的交感神经反应受损。