Kihara M, Takahashi A, Sugenoya J, Kihara Y, Watanabe H
Department of Internal Medicine, Daini Hospital, Tokyo Women's Medical College, Japan.
Funct Neurol. 1994 Jul-Aug;9(4):193-7.
We performed a quantitative sudomotor function test on 11 patients with classic amyotrophic lateral sclerosis (ALS) and 11 age-matched control subjects. Thermal warming increased the sweat rate in the forearm of ALS patients and in the forearm and thigh of control subjects. The sweat rate in the thigh of ALS patients was lower than that of controls. Thyrotropin releasing hormone increased the sweat rate in the forearm and thigh and decreased oral temperature in both ALS and controls but the lower extremity response was reduced in ALS. Results of the sudomotor axon reflex test on the thigh indicate that in ALS, there is mild postganglionic sudomotor dysfunction. We conclude that patients with ALS have mild thermoregulatory sweat dysfunction due to postganglionic lesions in the lower extremities.
我们对11例经典型肌萎缩侧索硬化症（ALS）患者和11名年龄匹配的对照受试者进行了定量汗腺功能测试。热刺激使ALS患者前臂以及对照受试者前臂和大腿的出汗率增加。ALS患者大腿的出汗率低于对照组。促甲状腺激素释放激素使ALS患者和对照受试者的前臂和大腿出汗率增加，并降低口腔温度，但ALS患者下肢的反应减弱。大腿汗腺轴突反射测试结果表明，ALS患者存在轻度节后汗腺功能障碍。我们得出结论，ALS患者由于下肢节后神经损伤而存在轻度体温调节性出汗功能障碍。
