维生素E、硒和β-胡萝卜素对大鼠心脏、肾脏、肺和脾脏中血红素蛋白的氧化损伤保护作用。
Protection of heme proteins by vitamin E, selenium, and beta-carotene against oxidative damage in rat heart, kidney, lung and spleen.
作者信息
Chen H, Tappel A L
机构信息
Department of Food Science and Technology, University of California, Davis 95616.
出版信息
Free Radic Res Commun. 1993;19(3):183-90. doi: 10.3109/10715769309111601.
Effects of the combination of vitamin E, selenium, and beta-carotene on oxidative damage to rat heart, kidney, lung, and spleen were studied by measurement of the production of oxidized heme proteins (OHP) during spontaneous and prooxidant-induced oxidation. Male SD rats were fed with a vitamin E and selenium deficient diet or a diet supplemented with vitamin E, selenium, and beta-carotene. Homogenates of heart, kidney, lung, and spleen were incubated at 37 degrees C with and without the presence of bromotrichloromethane (CBrCl3). The diet supplemented with antioxidants showed a strong protective effect against oxidative damage to heme proteins during the early stages of both spontaneous and CBrCl3-induced oxidation in contrast to the antioxidant deficient diet. Synergism of multiple antioxygenic nutrients against oxidative damage to various animal tissues is discussed.
通过测量在自发氧化和促氧化剂诱导的氧化过程中氧化血红素蛋白（OHP）的产生，研究了维生素E、硒和β-胡萝卜素组合对大鼠心脏、肾脏、肺和脾脏氧化损伤的影响。雄性SD大鼠喂食维生素E和硒缺乏的饮食或补充维生素E、硒和β-胡萝卜素的饮食。心脏、肾脏、肺和脾脏的匀浆在37℃下分别在有和没有溴三氯甲烷（CBrCl3）存在的情况下孵育。与抗氧化剂缺乏的饮食相比，补充抗氧化剂的饮食在自发氧化和CBrCl3诱导氧化的早期阶段对血红素蛋白的氧化损伤显示出强大的保护作用。讨论了多种抗氧化营养物质对各种动物组织氧化损伤的协同作用。
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