Lin D, Lan T
Hua Xi Yi Ke Da Xue Xue Bao. 1993 Jun;24(2):156-9.
This study adopted intracellular microelectrode technique to observe synchronously the effects of vesnarinone on intracellular potential and muscle tension of isolated rabbit's ventricular papillary muscle and analysed their variation. The results showed that vesnarinone increased the Tmax (P < 0.01) and Tdv/dt (P < 0.01) of isolated rabbit's ventricular papillary muscle and prolonged the action potential time (APT) without obvious effects on RP, APA and Vmax of papillary muscle. The relationship between them (r = 0.994, P < 0.05), suggesting that their changes be of the same mechanism and probably relate to the increase of inward calcium current.
本研究采用细胞内微电极技术，同步观察了维司力农对离体兔心室乳头肌细胞内电位和肌张力的影响，并分析了其变化情况。结果显示，维司力农可增加离体兔心室乳头肌的Tmax（P<0.01）和Tdv/dt（P<0.01），并延长动作电位时间（APT），而对乳头肌的RP、APA和Vmax无明显影响。二者之间存在相关性（r=0.994，P<0.05），提示它们的变化具有相同机制，可能与内向钙电流增加有关。
