Yang L, Chen D, Xu S, Yang T
Hua Xi Yi Ke Da Xue Xue Bao. 1993 Jun;24(2):216-8.
The mucosa of 46 patients with histological chronic gastritis were cultured for helicobacter pylori (HP) and the ammonia and urea in their gastric juice were also determined. The results showed the average ammonia concentration (1.22 +/- 0.23 mmol/L) in HP positive patients was higher than that of HP negative patients (0.72 +/- 0.25 mmol/L), (P < 0.05). But the average urea concentration (0.45 +/- 0.29 mmol/L) in HP positive patients was lower than that of HP negative patients (2.71 +/- 1.20 mmol/L), (P < 0.05). The higher the level of ammonia stands, the more severe the gastritis is. (rs = 0.556). On the other hand, the quantity of mucus was elevated in 18 patients among 28 patients with HP eradicated by drug treatment, which was significantly different from the patients with HP not eradicated. It is suggested that the epithelium of gastric mucosa and the mucus are the chief components of the gastric mucosa barrier; the presence of HP increases ammonia, and thus damages the gastric epithelium and reduces the quantity of mucus. Consequently, the protective gastric mucosa barrier is damaged, and then comes the liability to HP-associated gastritis.
对46例组织学诊断为慢性胃炎的患者的胃黏膜进行幽门螺杆菌（HP）培养，并测定其胃液中的氨和尿素含量。结果显示，HP阳性患者的平均氨浓度（1.22±0.23mmol/L）高于HP阴性患者（0.72±0.25mmol/L），（P<0.05）。但HP阳性患者的平均尿素浓度（0.45±0.29mmol/L）低于HP阴性患者（2.71±1.20mmol/L），（P<0.05）。氨水平越高，胃炎越严重。（rs=0.556）。另一方面，在28例经药物治疗根除HP的患者中，有18例患者的黏液量增加，这与未根除HP的患者有显著差异。提示胃黏膜上皮和黏液是胃黏膜屏障的主要组成部分；HP的存在会增加氨，从而损害胃上皮并减少黏液量。因此，胃黏膜保护屏障受损，进而易患HP相关性胃炎。
