通过原位杂交将人类聚集蛋白聚糖基因AGC1定位于15q25→q26.2。
Assignment of the human aggrecan gene AGC1 to 15q25-->q26.2 by in situ hybridization.
作者信息
Just W, Klett C, Vetter U, Vogel W
机构信息
Abteilung Klinische Genetik, Universität Ulm, Germany.
出版信息
Hum Genet. 1993 Nov;92(5):516-8. doi: 10.1007/BF00216462.
PMID:8244345
Abstract
The human aggrecan gene (AGC1) has been localized to 15q25-->q26.2 by in situ hybridization. Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan. This raises the possibility that AGC1 and mel-CSPG may be the same gene.
摘要
通过原位杂交技术，已将人类聚集蛋白聚糖基因（AGC1）定位于15q25→q26.2。尽管尚无结缔组织遗传病定位于此区域，但恶性黑色素瘤相关表面抗原mel-CSPG位于此处；mel-CSPG是一种硫酸软骨素蛋白聚糖。这就增加了AGC1和mel-CSPG可能是同一基因的可能性。
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