5-芳氧基-6-甲氧基-8-氨基喹啉作为潜在的抗疟预防药物。

5-Aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials.

作者信息

Paul K, Blanton C D

出版信息

J Pharm Sci. 1976 Oct;65(10):1527-30. doi: 10.1002/jps.2600651028.

Abstract

5-(p-Anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the Plasmodium berghei and monkey prophylactic (Plasmodium cynomolgi) tests. A new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. None of these compounds showed significant antimalarial or prophylactic activity.

摘要

重新合成了5-(对甲氧基苯氧基)-6-甲氧基-8-(5-异丙氨基戊基氨基)喹啉，以在伯氏疟原虫和猴疟预防性（食蟹猴疟原虫）试验中进行评估。还制备了一种新的伯胺、三种仲胺和5-芳氧基系列的一种结构修饰的侧链类似物。这些化合物均未显示出显著的抗疟或预防活性。