Teepe R G, Roseeuw D I, Hermans J, Koebrugge E J, Altena T, de Coninck A, Ponec M, Vermeer B J
Department of Dermatology, University Hospital, Leiden, The Netherlands.
J Am Acad Dermatol. 1993 Dec;29(6):982-8. doi: 10.1016/0190-9622(93)70278-2.
Cultured epidermal allografts have been successfully used to treat a variety of wounds. Their postulated mechanism of action is through release of cytokines that stimulate epithelialization. On the basis of previous experience we expected ulcers treated with cryopreserved cultured allografts (CCAs) to be healed by 6 weeks. Hydrocolloid dressings (HCDs) have also been reported to be effective in the treatment of venous ulcers.
Our purpose was to compare the effectiveness of CCAs with HCDs in healing chronic venous ulcers.
Forty-three patients with 47 ulcers were enrolled in a randomized controlled trial. Ulcers not healed by 6 weeks were changed to the other treatment.
No difference in the number of healed ulcers between the two groups was observed at 6 weeks. Healing rate, percent reduction of initial ulcer size, and radial progression toward wound closure were significantly greater for CCAs than for HCDs. Pain relief was not significantly different.
CCAs achieve more rapid healing and greater reduction in ulcer size than HCDs.
培养的同种异体表皮已成功用于治疗多种伤口。其假定的作用机制是通过释放刺激上皮形成的细胞因子。根据以往经验，我们预计用冷冻保存的培养同种异体移植物（CCA）治疗的溃疡在6周内愈合。据报道，水胶体敷料（HCD）在治疗静脉溃疡方面也有效。
我们的目的是比较CCA与HCD在愈合慢性静脉溃疡方面的有效性。
43例患有47处溃疡的患者参加了一项随机对照试验。6周内未愈合的溃疡改为另一种治疗方法。
6周时两组愈合溃疡数量无差异。CCA的愈合率、初始溃疡大小的减少百分比以及伤口闭合的径向进展均显著高于HCD。疼痛缓解无显著差异。
与HCD相比，CCA能实现更快的愈合和更大程度的溃疡大小缩小。
