Coleman W P, Lawrence N, Sherman R N, Reed R J, Pinski K S
J Dermatol Surg Oncol. 1993 Nov;19(11):1032-40. doi: 10.1111/j.1524-4725.1993.tb00996.x.
Soft tissue augmentation with processed fat has been used clinically for several years. This material has been termed "autologous collagen" since it was presumed it was composed primarily of collagen and fibrous tissue from lipocyte cell walls.
To examine the histologic behavior of dermis implanted with processed fat.
Volunteers were injected with processed fat intradermally in the post auricular area and these sites were biopsied at one week, one month, and three months.
Early biopsies revealed no intact adiopocytes but a significant inflammatory infiltrate. Subsequently biopsies revealed replacement of the inflammatory reaction with cellular fibrosis and expansion of the dermis.
Intradermal injection of processed fat results in deposition of fibrous material and collagen due to the response of the recipient site. The material itself contains very little collagen.
使用经过处理的脂肪进行软组织填充已在临床上应用数年。这种材料被称为“自体胶原蛋白”，因为据推测它主要由来自脂肪细胞壁的胶原蛋白和纤维组织组成。
研究植入经过处理的脂肪的真皮的组织学行为。
志愿者在耳后区域皮内注射经过处理的脂肪，这些部位在1周、1个月和3个月时进行活检。
早期活检显示没有完整的脂肪细胞，但有大量炎性浸润。随后的活检显示炎症反应被细胞纤维化取代，真皮扩张。
皮内注射经过处理的脂肪会因受区的反应而导致纤维材料和胶原蛋白的沉积。该材料本身含有的胶原蛋白很少。
