Uemura T, Nagayama M, Kawashima M
Department of Dermatology, Tokyo Women's Medical College, Japan.
J Dermatol. 1993 Aug;20(8):478-82. doi: 10.1111/j.1346-8138.1993.tb01324.x.
A case of a five-year-old Japanese boy with herpes-associated erythema multiforme (HAEM) was reported. The patient had eleven recurrences of herpes labiaris within one year; four of these recurrences were accompanied by erythema multiforme. A study of the human leukocyte antigens revealed the presence of HLA-DQW3, which has been reported to be significantly frequent in Caucasian patients with HAEM. Oral administration of acyclovir at the onset of herpes labialis was effective in preventing HAEM. Early administration of oral steroids at the onset of HAEM also prevented its exacerbation.
报告了一例5岁日本男孩患疱疹相关性多形红斑（HAEM）的病例。该患者在一年内唇疱疹复发11次；其中4次复发伴有多形红斑。对人类白细胞抗原的研究显示存在HLA - DQW3，据报道在白种人HAEM患者中该抗原出现频率显著较高。唇疱疹发作时口服阿昔洛韦对预防HAEM有效。HAEM发作时早期口服类固醇也可防止病情加重。
