Department of Dermatology, Sapienza University of Rome, Sant'Andrea General Hospital, Rome, Italy.
Faculty of Medicine, U.O.C. Dermatology, Policlinico Umberto I, University of Rome "Sapienza", Rome, Italy.
Dermatol Ther. 2019 May;32(3):e12847. doi: 10.1111/dth.12847. Epub 2019 Feb 10.
Erythema multiforme (EM) is an immune-mediated reaction characterized by target lesions and with possible mucosal involvement. Its most frequent cause is HSV, with HSV-1 more common than -2. It is usually self-limited but it can show recurrences. We report a peculiar case of recurrent herpes-associated erythema multiforme (HAEM) in a 35-year-old man. The patient was affected by both herpes labialis and genitalis, but the typical target lesions were only associated with recurrent herpes labialis. Here, we hypothesize about the pathogenic differences between HSV-1 and HSV-2, and discuss the therapeutic management of HAEM.
多形红斑（EM）是一种免疫介导的反应，其特征为靶病变，可能伴有黏膜受累。其最常见的病因是单纯疱疹病毒（HSV），其中 HSV-1 比 HSV-2 更为常见。它通常是自限性的，但也可能反复发作。我们报告了一例 35 岁男性复发性疱疹相关性多形红斑（HAEM）的特殊病例。该患者患有唇疱疹和生殖器疱疹，但典型的靶病变仅与复发性唇疱疹相关。在这里，我们假设 HSV-1 和 HSV-2 之间的发病机制差异，并讨论 HAEM 的治疗管理。
