Matsumoto J
Department of Chemistry, University of Massachusetts, Amherst 01003.
J Theor Biol. 1993 Oct 7;164(3):307-19. doi: 10.1006/jtbi.1993.1156.
A model for eukaryotic DNA damage repair is proposed in which poly(ADP-ribose) polymerase(NAD+ ADP-ribosyl transferase, EC 2,4,2,30) plays an important role. In this model, poly(ADP-ribose) polymerase regulates transcription of genes that are induced by DNA-damaging agents. This transcriptional regulation results from poly(ADP-ribosyl)ation and inactivation of DNA sequence-specific regulatory proteins such as silencer element-binding proteins, thereby inducing transcription of DNA polymerase beta, which is a DNA repair enzyme in higher eukaryotes. Poly(ADP-ribose) polymerase has a number of similarities to RecA in Escherichia coli. Therefore, the genes related to DNA damage repair in higher eukaryotes are proposed to form a "poly(ADP-ribose) polymerase regulatory network" similar to the "SOS regulatory network" in E. coli.
提出了一种真核生物DNA损伤修复模型，其中聚（ADP - 核糖）聚合酶（NAD + ADP - 核糖基转移酶，EC 2,4,2,30）起着重要作用。在该模型中，聚（ADP - 核糖）聚合酶调节由DNA损伤剂诱导的基因转录。这种转录调节是由于聚（ADP - 核糖基）化以及DNA序列特异性调节蛋白（如沉默子元件结合蛋白）的失活，从而诱导DNA聚合酶β的转录，DNA聚合酶β是高等真核生物中的一种DNA修复酶。聚（ADP - 核糖）聚合酶与大肠杆菌中的RecA有许多相似之处。因此，有人提出高等真核生物中与DNA损伤修复相关的基因会形成一个类似于大肠杆菌中“SOS调节网络”的“聚（ADP - 核糖）聚合酶调节网络”。
