Garcia A G, Fonseca M E, de Bonis M, Ramos H I, Ferro Z P, Nascimento J P
Departamento de Anatomia Patológica, Instituto Fernandes Figueira-FIOCRUZ, Rio de Janeiro, Brasil.
Mem Inst Oswaldo Cruz. 1993 Jan-Mar;88(1):141-7. doi: 10.1590/s0074-02761993000100022.
Pulmonary lesions compatible with adenovirus infection were detected by gross and microscopic examination of autopsy tissues from children aged from 5 to 34 months. Hepatic lesions indicative of systemic infection were also found in four of the children. The viral etiology was confirmed in three cases by in-situ hybridization, electron-microscopy and immunofluorescence performed in paraffin-embedded tissues, and in one case by cell culture isolation of adenovirus type 2 from nasopharyngeal exudate. Routine testing by methods additional to conventional light microscopy would probably have revealed a larger number of adenovirus infections among the 1,103 autopsy records analyzed in this study.
