Osamura T, Mizuta R, Yoshioka H, Fushiki S
Department of Paediatrics, Kyoto Second Red Cross Hospital, Japan.
Eur J Pediatr. 1993 Jun;152(6):496-9. doi: 10.1007/BF01955058.
We describe a fatal case of adenovirus pneumonia accompanied by encephalitis in a neonate who showed lethargy on the 6th day and died on the 12th day. Adenoviral particles as well as viral intranuclear inclusions were noted in pulmonary alveolar epithelium cells. Neuropathological examination revealed diffuse oedema, perivascular cuffing and gliosis in the white matter. Adenovirus type 11 was isolated from lung, hilar lymph node, and brain tissue. This is the first instance of adenovirus isolation from brain tissue in a newborn infant. The virological and neuropathological findings suggest the invasion of neural tissue by adenovirus and substantiate the significance of neurological symptoms observed in neonatal adenovirus infection.
我们描述了一例新生儿腺病毒肺炎伴脑炎的致死病例，该患儿在第6天出现嗜睡，于第12天死亡。在肺泡上皮细胞中发现了腺病毒颗粒以及病毒核内包涵体。神经病理学检查显示白质弥漫性水肿、血管周围套袖样浸润和神经胶质增生。从肺、肺门淋巴结和脑组织中分离出11型腺病毒。这是首次从新生儿脑组织中分离出腺病毒。病毒学和神经病理学发现提示腺病毒侵袭神经组织，并证实了新生儿腺病毒感染中观察到的神经症状的重要性。
