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果蝇的光感受器突变体:蛋白质是否参与光转导的中间步骤?

Photoreceptor mutant of Drosophia: is protein involved in intermediate steps of phototransduction?

作者信息

Paj W K, Istrit S E, Deland M C, Wu C F

出版信息

Science. 1976 Nov 26;194(4268):956-9. doi: 10.1126/science.824732.

Abstract

In norpA mutants of Drosophila melanogaster the phototransduction process is either partially or completely blocked. By using a temperature-sensitive allele, we have found that that norpA mutation has little or no effect on either the rhodopsin-metarhodopsin transition or the machinery of quantum bump production. Thus, the norpA lesion appears to be localized in the intermediate process of phototransduction. Because a temperature-sensitive allele of norpA has been isolated, the norpA gene probably encodes a protein involved in the process.

摘要

在黑腹果蝇的norpA突变体中,光转导过程部分或完全受阻。通过使用一个温度敏感等位基因,我们发现norpA突变对视紫红质-变视紫红质转变或量子突增产生机制几乎没有影响。因此,norpA损伤似乎定位于光转导的中间过程。由于已分离出norpA的温度敏感等位基因,norpA基因可能编码一种参与该过程的蛋白质。

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