Wikström M, Renvert S, Johnsson T, Dahlén G
Department of Oral Microbiology, Faculty of Odontology, University of Göteborg, Sweden.
Oral Microbiol Immunol. 1993 Aug;8(4):213-8. doi: 10.1111/j.1399-302x.1993.tb00562.x.
Duplicate samples from 110 periodontal sites of 6 mm or more pocket depth in 16 patients were analyzed for the presence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Capnocytophaga spp., Campylobacter rectus, Eikenella corrodens and Fusobacterium nucleatum. The sites were sampled before and after nonsurgical periodontal treatment. No statistically significant associations were found before treatment between any of the analyzed species. After treatment, statistically significant associations were found between E. corrodens and all the other species, F. nucleatum and P. intermedia; Capnocytophaga spp. and C. rectus; P. intermedia vs Capnocytophaga spp. and P. gingivalis; and C. rectus vs Capnocytophaga spp. and A. actinomycetemcomitans. Some of these associations could be explained either by patient-related factors or site-related characteristics such as the pocket depth. The proportion of P. gingivalis seemed to be unrelated to the proportion of P. intermedia in the samples. If one of the analyzed microbes was found in one of the sampled pockets in a patient, the probability of finding that microbe in all the sampled sites in the same patient before treatment was more than 50%. This probability was reduced after treatment for many species, especially P. gingivalis, which showed a probability of zero. The probability of detecting a bacterial species on at least one additional site if it was present on one in the same individual was nearly 100%, both before and after treatment, for all species studied. This study has shown several potential microbial associations in the subgingival plaque flora of deep periodontal pockets.(ABSTRACT TRUNCATED AT 250 WORDS)
对16例患者110个牙周袋深度达6毫米或更深的部位采集的重复样本进行分析，检测伴放线放线杆菌、牙龈卟啉单胞菌、中间普氏菌、二氧化碳嗜纤维菌属、直肠弯曲菌、腐蚀艾肯菌和具核梭杆菌的存在情况。这些部位在非手术牙周治疗前后均进行了采样。治疗前，在所分析的任何菌种之间均未发现具有统计学意义的关联。治疗后，发现腐蚀艾肯菌与所有其他菌种、具核梭杆菌与中间普氏菌、二氧化碳嗜纤维菌属与直肠弯曲菌、中间普氏菌与二氧化碳嗜纤维菌属及牙龈卟啉单胞菌、直肠弯曲菌与二氧化碳嗜纤维菌属及伴放线放线杆菌之间存在具有统计学意义的关联。其中一些关联可能由患者相关因素或部位相关特征（如牙周袋深度）来解释。样本中牙龈卟啉单胞菌的比例似乎与中间普氏菌的比例无关。如果在患者的一个采样牙周袋中发现了一种分析的微生物，那么在治疗前在该患者所有采样部位发现该微生物的概率超过50%。对许多菌种来说，治疗后这一概率降低，尤其是牙龈卟啉单胞菌，其概率降为零。对于所研究的所有菌种，无论治疗前后，如果在同一个体的一个部位检测到某一细菌菌种，那么在至少一个其他部位检测到该菌种的概率接近100%。本研究显示了深牙周袋龈下菌斑菌群中几种潜在的微生物关联。（摘要截短为250字）
