Sugiyama H, Fujimoto K, Hatano K, Ohmori K, Saito I
Division of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan.
Nucleic Acids Symp Ser. 1993(29):125-6.
In order to investigate the reactivity of uracilyl-5-yl radical in fixed DNA structure, photoreaction of 5-halouracil-containing oligonucleotides was investigated. It was found that photoirradiation of BrU-containing duplex DNA provided C1' oxidation product selectively at adenine residue of ABrU sequence. In contrast, photoirradiation of IU-containing DNA gave C1' and C2' oxidation products with almost no sequence preference. Sequence specific electron transfer in duplex DNA is proposed in the photoreaction of ABrU.
