Haraguchi K, Itoh Y, Tanaka H, Miyasaka T
School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Nucleic Acids Symp Ser. 1993(29):31-2.
Stereoselective synthesis of 1'-carbon-substituted uracil nucleosides has been achieved through face-selective bromo-pivaloyloxylation of a 1',2'-unsaturated derivative and successive SnCl4-promoted nucleophilic substitution with organosilicon reagents. This constitutes the first example of C-C bond formation at the anomeric position of nucleosides.
