Torikata C, Takeuchi H, Yamaguchi H, Kageyama K
Virchows Arch A Pathol Anat Histol. 1976 Aug 23;371(2):121-9. doi: 10.1007/BF00444928.
Atypical cilia in the bronchial mucosa of non-smoking women and in guinea-pig lungs were studied by the electron microscope. In human cases, numerous compound cilia were observed in the main bronchi. The largest one contained about 40 axial filament complexes in a ciliary shaft. Occasionally, atypical basal bodies were also seen. In the experimental model in guniea-pigs, 50% oxygen at one atmospheric pressure damaged the bronchial surface and resulted in degeneration and reduction of cilia and pellicular structures. The injury was not sufficiently severe to initiate adaptation and reparative mechanisms in the bronchial mucosa, and rapid renewal of the surface structures was found. The human cases were associated with bronchogenic carcinoma but the experimental model suggested that atypical cilia were not always related to pulmonary carcinogenesis.
通过电子显微镜研究了不吸烟女性支气管黏膜和豚鼠肺中的非典型纤毛。在人类病例中，在主支气管中观察到大量复合纤毛。最大的一个在纤毛轴中含有约40个轴丝复合体。偶尔也可见到非典型基体。在豚鼠实验模型中，一个大气压下50%的氧气会损伤支气管表面，导致纤毛和膜状结构退化和减少。这种损伤不足以严重到启动支气管黏膜的适应和修复机制，且发现表面结构能快速更新。人类病例与支气管癌有关，但实验模型表明非典型纤毛并不总是与肺癌发生相关。
