Velasco Plaza A, G-Granda T, Cachero M T
Department of Physiology, Faculty of Medicine, University of Oviedo, Spain.
Physiol Behav. 1993 Oct;54(4):665-70. doi: 10.1016/0031-9384(93)90074-p.
The light/dark (L/D) rhythms of food and water intake and urine output were studied in normal and diabetic rats for 7 consecutive days at 4-h intervals. The control rats showed the highest values of these parameters during the dark phase (83.68% food, 68.71% water, and 67.44% urine). The diabetic rats also maintained this nocturnal predominance, although the values were less marked (59.55% food, 55% water, and 56% urine). A circadian rhythm of food (phi = 3.31 h) and water (phi = 3.54 h) intake as well as of the volume of urine excreted (phi = 1.10) was detected in the control animals. The diabetic rats, inspite of presenting polyphagia, maintain the circadian rhythm of food intake, whereas a loss of the normal circadian variation of drinking intake was observed as well as the absence of circadian rhythm in urinary excretion. It was concluded that in streptozotocin-diabetic rats we have observed a loss of the normal patterns of water intake and urinary excretion, perhaps masked by the polydipsia and polyuria, whereas the circadian rhythm of food intake remains.
在正常大鼠和糖尿病大鼠中，以4小时为间隔连续7天研究了食物和水摄入以及尿量的光/暗（L/D）节律。对照大鼠在黑暗阶段这些参数的值最高（食物83.68%、水68.71%、尿液67.44%）。糖尿病大鼠也保持这种夜间优势，尽管数值不太明显（食物59.55%、水55%、尿液56%）。在对照动物中检测到食物摄入（φ = 3.31小时）、水摄入（φ = 3.54小时）以及排尿量（φ = 1.10）的昼夜节律。糖尿病大鼠尽管存在多食，但仍保持食物摄入的昼夜节律，然而观察到饮水摄入的正常昼夜变化丧失，以及尿排泄无昼夜节律。得出的结论是，在链脲佐菌素诱导的糖尿病大鼠中，我们观察到水摄入和尿排泄的正常模式丧失，可能被烦渴和多尿掩盖，而食物摄入的昼夜节律仍然存在。
