Rushing P A, Mittleman G
Department of Psychology, Memphis State University, TN 38152.
Physiol Behav. 1993 Nov;54(5):927-30. doi: 10.1016/0031-9384(93)90304-x.
The anorexic effects of phenylpropanolamine (PPA) appear to be qualitatively different in humans and rats. One factor that may account for these differences is that PPA is excreted essentially unchanged in humans, while nearly 30% is metabolized into 4-hydroxynorephedrine (4-OHN) in rats. To investigate the contribution of 4-OHN to the anorexic properties of PPA, this experiment compared the effects of equal doses (0.0-20.0 mg/kg, IP) of both drugs on eating and drinking during restricted feeding trials in the same group of food-deprived, female rats. Both 15.0 and 20.0 mg/kg of PPA significantly decreased eating when compared to saline vehicle, while 5.0-20.0 mg/kg of the drug reduced prandial drinking. In comparison, only the highest dose of 4-OHN (20.0 mg/kg) significantly suppressed food and water intake. When the percentage of reduction produced by corresponding doses of the two drugs was compared, PPA proved to be more than twice as potent as 4-OHN. It is concluded that, at the doses used, 4-OHN is unlikely to significantly contribute to reductions in deprivation-induced eating produced by the acute administration of PPA.
苯丙醇胺（PPA）对人类和大鼠的厌食作用在性质上似乎有所不同。一个可能解释这些差异的因素是，PPA在人体内基本以原形排泄，而在大鼠体内近30%会代谢为4-羟基去甲麻黄碱（4-OHN）。为了研究4-OHN对PPA厌食特性的作用，本实验在同一组饥饿的雌性大鼠的限食试验中，比较了两种药物等剂量（0.0 - 20.0 mg/kg，腹腔注射）对进食和饮水的影响。与生理盐水载体相比，15.0和20.0 mg/kg的PPA均显著减少进食，而5.0 - 20.0 mg/kg的该药物减少了餐时饮水。相比之下，只有最高剂量的4-OHN（20.0 mg/kg）显著抑制食物和水的摄入量。当比较两种药物相应剂量产生的减少百分比时，PPA的效力被证明是4-OHN的两倍多。得出的结论是，在所使用的剂量下，4-OHN不太可能对急性给予PPA引起的剥夺诱导进食减少有显著作用。
