Mittleman G, Rushing P A, Winders S E
Department of Psychology, Memphis State University, TN 38152.
Physiol Behav. 1993 Sep;54(3):515-21. doi: 10.1016/0031-9384(93)90245-b.
This experiment examined the effects of phenylpropanolamine (0.0, 5.0, 10.0, 20.0 mg/kg PPA) on regulatory (RG) and nonregulatory (NRG) eating and drinking in rats using a within-subjects design. Administration of PPA produced dose-dependent reductions in eating in animals deprived to 80-85% of baseline weight, and reduced drinking after 23.5-h of water deprivation. Nonregulatory eating, elicited by tail pinch in nondeprived animals, was similarly inhibited. Nonregulatory drinking was elicited in the schedule-induced polydipsia (SIP) paradigm. Water consumption, locomotion, licking, lick efficiency (licks/ml water), and entries into the food magazine were simultaneously measured. At the lowest dose, only locomotion was significantly reduced. At 10.0 mg/kg, lick efficiency and entries into the food magazine were also significantly reduced, while all measured behaviors, including licking and water consumption, were decreased by the highest dose of PPA. The reduction in lick efficiency suggested a PPA-induced motor impairment in the capacity for licking. Considered together, these results indicated that the observed decreases in regulatory and nonregulatory eating and drinking could be at least partially accounted for by the drug's effects on behaviors contributing to ingestion, as well as apparent motor impairments in ingestive behavior at higher doses.
本实验采用被试内设计，研究了苯丙醇胺（0.0、5.0、10.0、20.0毫克/千克苯丙醇胺）对大鼠调节性（RG）和非调节性（NRG）进食及饮水的影响。给体重降至基线体重80 - 85%的动物注射苯丙醇胺后，进食量出现剂量依赖性减少，且在禁水23.5小时后饮水量也减少。在未禁食动物中，通过夹尾引发的非调节性进食同样受到抑制。在定时诱导多饮（SIP）范式中引发非调节性饮水。同时测量了饮水量、活动量、舔舐次数、舔舐效率（舔舐次数/毫升水）以及进入食盒的次数。在最低剂量时，仅活动量显著减少。在10.0毫克/千克时，舔舐效率和进入食盒的次数也显著减少，而在最高剂量的苯丙醇胺作用下，所有测量行为，包括舔舐和饮水量，均减少。舔舐效率的降低表明苯丙醇胺导致了舔舐能力的运动障碍。综合来看，这些结果表明，观察到的调节性和非调节性进食及饮水减少，至少部分可归因于药物对进食行为相关行为的影响，以及高剂量时对摄食行为明显的运动障碍。
