Early Candida isolations in febrile patients after abdominal surgery.

The significance of finding Candida sp. in febrile patients after abdominal surgery was studied in a prospective study on 107 patients. The patients were divided into 3 groups, based on the isolation and time of sampling of Candida sp. and on any other microbiological documentation of the infection. Eight patients were found Candida-positive either by blood cultures or by cultures of urine, abdominal pus, tracheal aspirate or wound exudate within the first postoperative week and had significantly greater mortality than patients with other infections or later Candida sp.-isolation (50% vs 10%, p < 0.05). Isolation of Candida was associated with prolonged antibiotic therapy, extended central vein catheterization, parenteral nutrition and operations on the small bowel, ascending colon or pancreas, but not with the underlying illness. The results support the view that isolation of Candida sp. within the first week after surgery does not represent harmless colonization but is rather associated with serious morbidity.