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1982 - 1992年芬兰的川崎病

Kawasaki disease in Finland in 1982-1992.

作者信息

Salo E

机构信息

Helsinki University Children's Hospital, Finland.

出版信息

Scand J Infect Dis. 1993;25(4):497-502. doi: 10.3109/00365549309008532.

Abstract

Data on patients suffering from Kawasaki disease have been collected prospectively in Finland since 1981. To ascertain the incidence, treatment and outcome in these patients the data were analysed for the 10-year period April 1982 to March 1992. Kawasaki disease was confirmed in 229 patients. The annual attack rate varied from 3.1 to 7.2 per 100,000 children below the age of 5 years. Their mean age was 3.9 years (range: 7 weeks to 39 years). 40% were under 2 years and 71% under 5 years of age. There was 1 adult patient. The male/female ratio was 1.5:1. Coronary artery lesions were found in 28 patients, 2 of whom died of myocardial infarction. Since April 1985, 132 patients (73%) have been treated with intravenous immunoglobulin. When treatment was begun before day 7 of the disease, coronary artery lesions were found in 5.5%; when begun between days 7 and 10, in 12%, and when begun after day 10, in 28% of the patients.

摘要

自1981年以来,芬兰一直在前瞻性地收集川崎病患者的数据。为了确定这些患者的发病率、治疗方法和治疗结果,对1982年4月至1992年3月这10年期间的数据进行了分析。确诊川崎病的患者有229例。5岁以下儿童的年发病率为每10万人3.1至7.2例。他们的平均年龄为3.9岁(范围:7周龄至39岁)。40%的患者年龄在2岁以下,71%的患者年龄在5岁以下。有1例成年患者。男女比例为1.5:1。28例患者发现有冠状动脉病变,其中2例死于心肌梗死。自1985年4月以来,132例患者(73%)接受了静脉注射免疫球蛋白治疗。在疾病第7天之前开始治疗时,冠状动脉病变的发生率为5.5%;在第7至10天开始治疗时,发生率为12%;在第10天之后开始治疗时,发生率为28%。

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