Vaporciyan A A, DeLisser H M, Yan H C, Mendiguren I I, Thom S R, Jones M L, Ward P A, Albelda S M
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.
Science. 1993 Dec 3;262(5139):1580-2. doi: 10.1126/science.8248808.
During inflammation, neutrophils migrate from the vascular lumen into extravascular sites. In vitro assays have suggested that platelet-endothelial cell adhesion molecule-1 [PECAM-1 (CD31)], a member of the immunoglobulin superfamily, is required for the transmigration of neutrophils across endothelial monolayers. Antibody to human PECAM-1, which cross-reacts with rat PECAM-1, was found to block not only in vivo accumulation of rat neutrophils into the peritoneal cavity and the alveolar compartment of the lung but also neutrophil accumulation in human skin grafts transplanted onto immunodeficient mice. On the basis of these findings in three different models of inflammation, it appears that PECAM-1 is required for neutrophil transmigration in vivo and may thus be a potential therapeutic target.
在炎症过程中，中性粒细胞从血管腔迁移到血管外部位。体外实验表明，免疫球蛋白超家族成员血小板内皮细胞黏附分子-1 [PECAM-1 (CD31)] 是中性粒细胞跨内皮单层迁移所必需的。发现与人PECAM-1交叉反应的抗大鼠PECAM-1抗体不仅能阻断大鼠中性粒细胞在体内向腹膜腔和肺肺泡腔的积聚，还能阻断移植到免疫缺陷小鼠身上的人类皮肤移植物中的中性粒细胞积聚。基于这三种不同炎症模型的这些发现，似乎PECAM-1是体内中性粒细胞迁移所必需的，因此可能是一个潜在的治疗靶点。
