Muller W A
Rockefeller University, New York, NY 10021, USA.
Agents Actions Suppl. 1995;46:147-57. doi: 10.1007/978-3-0348-7276-8_15.
Platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) is expressed on the surfaces of neutrophils and monocytes and concentrated at the junctional surfaces of vascular endothelial cells. Monoclonal antibodies against PECAM-1 and soluble recombinant PECAM-1 selectively block the passage of these leukocytes across the endothelial monolayer without interfering with earlier adhesion events in the emigration pathway. This block is seen both in vitro and in several in vivo models of acute inflammation. Since PECAM-1 appears to be crucial for a distinct step in the emigration of leukocytes into a focus of inflammation, PECAM-1 appears to be a new and potentially important target for anti-inflammatory therapy.
血小板/内皮细胞黏附分子1（PECAM-1/CD31）在中性粒细胞和单核细胞表面表达，并集中在血管内皮细胞的连接表面。抗PECAM-1单克隆抗体和可溶性重组PECAM-1可选择性地阻断这些白细胞穿过内皮单层，而不干扰迁移途径中早期的黏附事件。这种阻断在体外和几种急性炎症的体内模型中均可见到。由于PECAM-1似乎在白细胞迁移到炎症灶的一个特定步骤中起关键作用，因此PECAM-1似乎是抗炎治疗的一个新的且潜在重要的靶点。
