Furihata M, Ohtsuki Y, Sonobe H, Araki K, Ogata T, Toki T, Ogoshi S, Tamiya T
Second Department of Pathology, Kochi Medical School, Japan.
Tohoku J Exp Med. 1993 Mar;169(3):187-95. doi: 10.1620/tjem.169.187.
The distribution of HLA-DR-positive dendritic cells (DR+DCs) and tumor infiltrating lymphocytes (TILs) was investigated in 67 patients with squamous cell carcinoma of the esophagus. DR+DCs were chiefly present among the cancer cell nests, and few were seen in the stroma. As clusters, UCHL-1-positive T-cells (UCHL1-Ts) were detected in the tissue around the cancer cell nests and as individual cells within tumor nests. Some UCHL1-Ts in the tumor nests showed direct contact with DR+DCs. In addition, a few OPD4-positive helper/inducer T cells were found among cancer cells, and were densely present in the stroma. A correlation was demonstrated between the number of DR+DCs and UCHL1-Ts in each patient (R = 0.4547, p < 0.01). In addition, dense tumor infiltration by both DR+DCs and UCHL1-Ts within the cancer cell nests was related to a better prognosis (p < 0.01).
对67例食管鳞状细胞癌患者的HLA - DR阳性树突状细胞（DR + DCs）和肿瘤浸润淋巴细胞（TILs）的分布进行了研究。DR + DCs主要存在于癌细胞巢中，在基质中较少见。UCHL - 1阳性T细胞（UCHL1 - Ts）以簇状形式在癌细胞巢周围组织中被检测到，并以单个细胞形式存在于肿瘤巢内。肿瘤巢中的一些UCHL1 - Ts与DR + DCs有直接接触。此外，在癌细胞中发现了一些OPD4阳性辅助/诱导性T细胞，且在基质中密集存在。在每位患者中，DR + DCs数量与UCHL1 - Ts数量之间存在相关性（R = 0.4547，p < 0.01）。此外，癌细胞巢内DR + DCs和UCHL1 - Ts的密集肿瘤浸润与较好的预后相关（p < 0.01）。
