Shloma D V, Sozans'kyĭ O O, Huleiuk N L, Akopian H R, Nevzhoda N V
Tsitol Genet. 1993 Jul-Aug;27(4):55-61.
Girls-teenagers and women with menstrual disturbances were examined cytogenetically and clinically with special respect to the thyroid function. The rate of chromosomal pathology in the studied group was 29.5%. The rate of aberrant cells proved to be elevated in cases of primary and secondary amenorrhea as compared with the control. Chromatid aberrations were typical of the Turner syndrome (8.1% as against 2.1% in controls). In cases of menstrual disturbances the C-segment macrovariants were detected in chromosomes 9 and 16, so as inverted C-segments. The thyroid hyperplasia of the 1st, 2nd stages was detected at the rate of 81.2% among the teenaged girls with menstrual disturbances and TSH-hypophysis-hyperfunction was typical of women with primary or secondary amenorrhea, providing evidence for the secondary origin of thyroid hormonal disturbances.
对患有月经紊乱的少女和女性进行了细胞遗传学和临床检查，特别关注甲状腺功能。研究组的染色体病理学发生率为29.5%。与对照组相比，原发性和继发性闭经患者的异常细胞率有所升高。染色单体畸变是特纳综合征的典型特征（8.1%，而对照组为2.1%）。在月经紊乱病例中，在9号和16号染色体上检测到C段大变异体以及倒位C段。在患有月经紊乱的少女中，1期和2期甲状腺增生的检出率为81.2%，原发性或继发性闭经的女性典型表现为促甲状腺激素-垂体-功能亢进，这为甲状腺激素紊乱的继发性起源提供了证据。
