Huleiuk N L
Tsitol Genet. 1994 May-Jun;28(3):75-9.
The frequency and the pattern of chromosomal aberrations as well as the frequency of metaphase plates with premature chromatid disjunction, polyploidy and endoreduplication were studied in lymphocyte cultures of women with disturbances of the menstrual function and in healthy women. The frequency of metaphase plates was significantly increased in persons with Turner's syndrome and reduced in the groups with amenorrhea 1 and 2 in comparison with the group of healthy women. There was no difference in chromosomal aberration pattern. Premature chromatid disjunction is characteristic of patients with disturbances of the menstrual function and healthy women. The frequency of metaphase plates with premature chromatid disjunction was elevated in groups with Turner's syndrome, amenorrhea 1 and premature sexual maturation in comparison with the control.
对月经功能紊乱的女性和健康女性的淋巴细胞培养物，研究了染色体畸变的频率和模式，以及具有早发性染色单体分离、多倍体和核内复制的中期板的频率。与健康女性组相比，特纳综合征患者的中期板频率显著增加，闭经1组和闭经2组的中期板频率降低。染色体畸变模式没有差异。早发性染色单体分离是月经功能紊乱患者和健康女性的特征。与对照组相比，特纳综合征组、闭经1组和性早熟组中具有早发性染色单体分离的中期板频率升高。
