Ibrahim N D, Kwanashie H O, Njoku C O, Olurinola P F
Department of Pathology and Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria.
Vet Hum Toxicol. 1993 Oct;35(5):399-402.
Forty-eight BALB/C mice (30 males, 18 females) and 18 male Wistar rats were given Kargasok tea in their drinking water. Zero, 15, 25, 50, 75 or 100% concentrations were administered to mice for 2 or 8 w while the rats were given 0, 15 or 50% concentrations of the beverage for 12 w. Neither the mice nor rat's organ/body weight ratios were significantly affected by treatment. Rats receiving 15 or 50% concentrations of the tea had nephropathy and non-suppurative necrosis of the duodenum, pancreas and intestine. No significant microscopic lesions were found in any treated mice even when given 100% concentration of the tea. These findings suggest species variation in susceptibility to toxicity from the tea. The tea may be a cause of renal failure, diabetes mellitus and malabsorption syndrome and may not be safe for human or animal consumption.
48只BALB/C小鼠（30只雄性，18只雌性）和18只雄性Wistar大鼠的饮用水中添加了卡尔加索克茶。分别以0%、15%、25%、50%、75%或100%的浓度给予小鼠饮用2周或8周，而给予大鼠0%、15%或50%浓度的该饮料，持续12周。处理对小鼠和大鼠的器官/体重比均无显著影响。接受15%或50%浓度茶的大鼠出现了肾病以及十二指肠、胰腺和肠道的非化脓性坏死。即使给予100%浓度的茶，在任何接受处理的小鼠中均未发现明显的微观病变。这些发现表明不同物种对该茶毒性的易感性存在差异。该茶可能是肾衰竭、糖尿病和吸收不良综合征的一个病因，对人类或动物饮用可能不安全。
