硫酸脱氢表雄酮对子宫颈张力的影响及其机制
[Effect of dihydroepiandrosterone sulfate on the tension of uterine cervix and its mechanisms].
作者信息
Zuo X C, Qiao F X, Wang N G, Zhou L F, Guan M Z
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
出版信息
Yao Xue Xue Bao. 1993;28(6):469-71.
PMID:8249606
Abstract
After i.v. injection of dihydroepiandrosterone sulfate (DHA-S) at 20 or 40 mg/kg to female rats on day 19 of gestation, the tension and hydroxyproline level of uterine cervix were decreased obviously. However, DHA-S at 10 mg/kg showed no effect on the tension of uterine cervix. DHA-S in vitro, at 0.1 mg/kg significantly increased estradiol secretion in the ovaries and placenta of late pregnant rats.
摘要
在妊娠第19天给雌性大鼠静脉注射20或40mg/kg硫酸脱氢表雄酮（DHA-S）后，子宫颈的张力和羟脯氨酸水平明显降低。然而，10mg/kg的DHA-S对子宫颈张力没有影响。体外实验中，0.1mg/kg的DHA-S显著增加了晚期妊娠大鼠卵巢和胎盘中雌二醇的分泌。
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