雌二醇和他莫昔芬对妊娠大鼠子宫颈胶原蛋白含量的影响。

Influence of estradiol and tamoxifen on collagen content in the uterine cervix of pregnant rats.

作者信息

Bienkiewicz A

机构信息

Institute of Obstetrics and Gynecology, Medical University of Lódz, Poland.

出版信息

Biol Signals. 1995 Mar-Apr;4(2):94-7. doi: 10.1159/000109427.

DOI:10.1159/000109427

PMID:8590918

Abstract

During late pregnancy, the uterine cervix of 42 rats (control n = 13, estradiol n = 17, tamoxifen n = 12) were analyzed for total collagen, its soluble fraction and water content. Symptoms of delivery were present on day 21 of gestation in 23.5% of the rats in the estradiol group but there were no similar symptoms on day 21 in the control and tamoxifen groups. The concentration of total and soluble collagen in the estradiol group was lower (p < 0.01) than in the control group. In the tamoxifen group, while the soluble collagen was lower (p < 0.01) than in the control group, the total collagen concentration was higher, but not significantly so.

摘要

在妊娠晚期，对42只大鼠（对照组n = 13，雌二醇组n = 17，他莫昔芬组n = 12）的子宫颈进行了总胶原蛋白、其可溶性部分和含水量的分析。雌二醇组23.5%的大鼠在妊娠第21天出现分娩症状，但对照组和他莫昔芬组在第21天没有类似症状。雌二醇组总胶原蛋白和可溶性胶原蛋白的浓度低于对照组（p < 0.01）。在他莫昔芬组中，虽然可溶性胶原蛋白低于对照组（p < 0.01），但总胶原蛋白浓度较高，但差异不显著。