青兰素A对兔血小板体外聚集及环磷酸腺苷水平的影响。
Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro.
作者信息
Zhang B, Long K
机构信息
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China.
出版信息
Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):347-50.
Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-, AA-, and PAF-induced aggregation of rabbit platelets with IC50 values of 3.44, 13.32, and 7.74 mumol.L-1, respectively. Gla A 10 and 100 mumol.L-1 increased the cAMP levels in platelets. In combination with imazodan hydrochloride, Gla A (1-100 mumol.L-1) caused a marked increase of platelet cAMP levels, while no effect with PGE1.
蓝萼甲素（Gla A）是从采自中国东北的唇形科植物蓝萼香茶菜（Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara）叶片的乙醚提取物中分离得到的一种新型二萜类化合物。当与洗涤过的兔血小板一起孵育时，蓝萼甲素抑制ADP、花生四烯酸（AA）和血小板活化因子（PAF）诱导的兔血小板聚集，IC50值分别为3.44、13.32和7.74 μmol·L-1。10和100 μmol·L-1的蓝萼甲素可提高血小板中的环磷酸腺苷（cAMP）水平。与盐酸伊马唑丹联合使用时，蓝萼甲素（1 - 100 μmol·L-1）可显著提高血小板cAMP水平，而与前列腺素E1（PGE1）联合使用则无此作用。
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