[胸腺因子D对老龄大鼠肝脏脂质过氧化物、谷胱甘肽及膜流动性的影响]
[Effect of thymic factor D on lipid peroxide, glutathione, and membrane fluidity in liver of aged rats].
作者信息
Li L, Zhou J H, Xing S T, Chen Z R
机构信息
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, Beijing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1993 Jul;14(4):382-4.
The effects of thymic factor D (TFD) on aging were investigated in male Wistar rats at the age of 24 months. Thymic factor, polypeptides extracted from swine thymus, was given to aged rats in the dose of 2 mg.kg-1 sc every other day for 3 months. It was shown that TFU decreased the content of malondialdehyde (MDA) and lipofuscin in the liver of aged rats, accompanied by an increase of glutathione (GSH). Besides, the declined fluidity of hepatic mitochondrial and microsomal membranes in aged rats was recovered to the level of young adult rats by administration of TFD. It is suggested that TFD may possess beneficial effects on retarding the senile metabolic changes in hepatic cells.
研究了胸腺因子D（TFD）对24月龄雄性Wistar大鼠衰老的影响。胸腺因子是从猪胸腺中提取的多肽，以2mg.kg-1的剂量隔日皮下注射给老龄大鼠，持续3个月。结果表明，TFD降低了老龄大鼠肝脏中丙二醛（MDA）和脂褐素的含量，同时谷胱甘肽（GSH）含量增加。此外，给予TFD后，老龄大鼠肝线粒体和微粒体膜流动性的下降恢复到了年轻成年大鼠的水平。提示TFD可能对延缓肝细胞衰老代谢变化具有有益作用。
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