Hong R
Department of Pediatrics, University of Wisconsin Medical School, Madison.
Adv Pediatr. 1993;40:101-24.
BMT has been successfully utilized in clinical medicine for nearly 25 years. Successful accomplishment of BMT has severely taxed the research and clinical capabilities of medical scientists, but the attainment of a cure for fatal disease has amply justified the efforts expended. The major problems still to be solved include better conditioning regimens, better control of GVHD, and enlargement of donor pools. The control of problems created by this therapy demands a thorough understanding of the immune system. As this knowledge increases, useful manipulation of immunity to control the hundreds of other diseases caused by aberrant immune processes should become possible. Soon, genetically engineered marrow transplants should be possible.
骨髓移植在临床医学中已成功应用了近25年。骨髓移植的成功实施极大地考验了医学科学家的研究和临床能力，但治愈致命疾病的成果充分证明了所付出的努力是值得的。仍有待解决的主要问题包括更好的预处理方案、更好地控制移植物抗宿主病以及扩大供体库。控制这种治疗所产生的问题需要对免疫系统有透彻的了解。随着这方面知识的增加，有可能对免疫进行有效操控，以控制由异常免疫过程引起的数百种其他疾病。很快，基因工程骨髓移植应该是可行的。
