Bonan R, Paiement P, Scortichini D, Cloutier M J, Leung T K
Department of Medicine, Montreal Heart Institute, Quebec, Canada.
Am Heart J. 1993 Dec;126(6):1334-40. doi: 10.1016/0002-8703(93)90531-d.
To investigate the mechanisms of restenosis and detect useful interventions to prevent it, reliable quantitative measurements must be evaluated. Coronary arteries of domestic and minipigs (n = 18) were mechanically injured by balloon overstretching and killed at different intervals (2 to 25 weeks) after quantitative angiographic analysis. Morphometric measurements evaluated intimal hyperplasia at 0.59 +/- 0.42 mm without relation to artery size or balloon/artery ratio. Intimal hyperplasia, expressed as the ratio of neointimal area to total wall area (A), is directly related to the injury, assessed by the ratio of internal elastic lamina (IEL) fracture length to IEL circumference (B), r = 0.84, p = 0.002. Restenosis injury index, defined as A/B, provides a useful tool for the quantitative assessment of future angioplasty-related restenosis interventions.
为了研究再狭窄的机制并寻找有效的预防干预措施，必须评估可靠的定量测量方法。对18头家猪和小型猪的冠状动脉进行球囊过度扩张机械损伤，并在定量血管造影分析后的不同时间间隔（2至25周）处死。形态测量评估内膜增生为0.59±0.42毫米，与动脉大小或球囊/动脉比值无关。内膜增生以新生内膜面积与总壁面积之比（A）表示，与损伤直接相关，损伤程度通过内弹性膜（IEL）断裂长度与IEL周长之比（B）评估，r = 0.84，p = 0.002。再狭窄损伤指数定义为A/B，为未来血管成形术相关再狭窄干预的定量评估提供了一个有用的工具。
