Boozer C N, Brasseur A, Atkinson R L
Medical Research Service, Department of Veterans' Affairs Medical Center, Hampton, VA 23667.
Am J Clin Nutr. 1993 Dec;58(6):846-52. doi: 10.1093/ajcn/58.6.846.
This study examined the effect of dietary fat during food restriction on weight loss, body composition, and adipose tissue lipoprotein lipase activity (ATLPL). Rats previously fed a high-fat diet were divided into four groups. One group served as baseline controls. The other three groups were fed diets of 12%, 28%, or 45% fat, restricted (R) in amounts to equal 75% of their previous ad libitum energy intake. After 10 wk, body weight loss and reduction of adiposity were significantly less in the 45%-R group compared with the 12%-R group (weight P < 0.05; adiposity P < 0.01). Rats fed restricted amounts of the high-fat diet (45%-R group) retained adiposity equivalent to baseline control rats. ATLPL activity was increased in the 45%-R group compared with baseline control rats. Further studies are needed in humans, but these results suggest that body composition will not be normalized with reduction of energy intake unless dietary fat is also reduced.
本研究考察了食物限制期间膳食脂肪对体重减轻、身体成分及脂肪组织脂蛋白脂肪酶活性（ATLPL）的影响。先前喂食高脂饮食的大鼠被分为四组。一组作为基线对照组。其他三组分别喂食脂肪含量为12%、28%或45%的饮食，食物量限制在先前自由摄食能量摄入量的75%。10周后，与12%-R组相比，45%-R组的体重减轻和肥胖程度降低显著较少（体重P<0.05；肥胖程度P<0.01）。喂食高脂肪饮食限制量的大鼠（45%-R组）保留的肥胖程度与基线对照大鼠相当。与基线对照大鼠相比，45%-R组的ATLPL活性增加。在人类中还需要进一步研究，但这些结果表明，除非减少膳食脂肪，否则仅通过减少能量摄入，身体成分不会恢复正常。
