肝硬化中的细菌感染，伴或不伴肝细胞癌。

Bacterial infection in cirrhosis, with and without hepatocellular carcinoma.

作者信息

Yoshida H, Hamada T, Inuzuka S, Ueno T, Sata M, Tanikawa K

机构信息

Second Department of Medicine, Kurume University School of Medicine, Japan.

出版信息

Am J Gastroenterol. 1993 Dec;88(12):2067-71.

PMID:8249975

Abstract

OBJECTIVE

The extent and type of bacterial infection occurring with liver cirrhosis has remained unknown. Further, while hepatocellular carcinoma (HCC) is known to occur mainly in patients with liver cirrhosis, no report has yet investigated the incidence of bacterial infection in HCC. The purpose of the present study was to establish the prevalence of bacterial infection in patients with HCC.

METHODS

We have retrospectively investigated all 1140 patients with hepatic cirrhosis and/or HCC for any incidence of bacterial infection.

RESULTS

The incidence of bacterial infection was found to be 15.4%, in 740 patients with HCC. This was approximately equal to the incidence of bacterial infection in 400 patients with cirrhosis without HCC, which was found to be 15.3%. When the severity of cirrhosis was graded according to Child-Pugh classification, the incidences of bacterial infection in Child-Pugh class A, class B, and class C were 3.3%, 11.1%, and 31.2%, respectively, in cirrhosis, and 2.3%, 9.1% and 25.6% in HCC. The incidence of bacterial infection increased with the severity of cirrhosis and severe bacterial infections occurred in Child-Pugh class B and C patients.

CONCLUSION

The data suggest that the susceptibility of HCC patients to bacterial infection is mainly related to the underlying cirrhosis and not to the HCC.

摘要

目的

肝硬化患者发生细菌感染的程度和类型尚不清楚。此外，虽然已知肝细胞癌（HCC）主要发生在肝硬化患者中，但尚无报告调查HCC患者细菌感染的发生率。本研究的目的是确定HCC患者细菌感染的患病率。

方法

我们回顾性调查了所有1140例肝硬化和/或HCC患者的细菌感染发生率。

结果

在740例HCC患者中，细菌感染发生率为15.4%。这与400例无HCC的肝硬化患者的细菌感染发生率大致相当，后者为15.3%。根据Child-Pugh分类法对肝硬化严重程度进行分级时，肝硬化患者中Child-Pugh A级、B级和C级的细菌感染发生率分别为3.3%、11.1%和31.2%，HCC患者中分别为2.3%、9.1%和25.6%。细菌感染发生率随肝硬化严重程度的增加而升高，严重细菌感染发生在Child-Pugh B级和C级患者中。