清醒纯种马重复呼吸期间一氧化碳肺弥散量和功能残气量的测量。

Measurement of pulmonary diffusing capacity for carbon monoxide and functional residual capacity during rebreathing in conscious thoroughbreds.

作者信息

Aguilera-Tejéro E, Pascoe J R, Amis T C, Kurpershoek C J, Woliner M J

机构信息

Department of Surgery, School of Veterinary Medicine, University of California-Davis 95616.

出版信息

Am J Vet Res. 1993 Oct;54(10):1752-7.

PMID:8250403

Abstract

A rebreathing method for measurement of pulmonary diffusing capacity for carbon monoxide (DLCO) and functional residual capacity (FRC) was evaluated in conscious horses. Horses were manually ventilated through an endotracheal tube, using a custom-made syringe filled with a gas mixture containing 18-carbon monoxide (18CO) and helium (He). The 18CO and He concentrations were continuously monitored by use of a mass spectrometer connected to the rebreathing circuit. Values for DLCO and FRC were calculated from changes in the concentration of these 2 gases. In 11 Thoroughbreds, mean (+/- SD) DLCO was 330.3 +/- 56.9 ml.min-1 x mm of Hg-1, and FRC was 20.21 +/- 3.35 L. Body weight normalization yielded mean (+/- SD) values of 0.652 +/- 0.114 ml.min-1 x mm of Hg-1 x kg-1 for DLCO, and 39.9 +/- 6.4 ml.kg-1 for FRC.

摘要

对一种用于测量清醒马匹一氧化碳肺弥散量（DLCO）和功能残气量（FRC）的重复呼吸法进行了评估。通过气管内导管对马匹进行人工通气，使用一个定制的注射器，其中装有含18-一氧化碳（18CO）和氦气（He）的气体混合物。通过连接到重复呼吸回路的质谱仪连续监测18CO和He的浓度。根据这两种气体浓度的变化计算出DLCO和FRC的值。在11匹纯种马中，平均（±标准差）DLCO为330.3±56.9 ml·min⁻¹×mmHg⁻¹，FRC为20.21±3.35 L。按体重标准化后，DLCO的平均（±标准差）值为0.652±0.114 ml·min⁻¹×mmHg⁻¹×kg⁻¹，FRC为39.9±6.4 ml·kg⁻¹。