Bouvrain Y, Coraboeuf E
Arch Mal Coeur Vaiss. 1976 Sep;69(9):873-81.
Over the last few years, much experimental work has been done to try and elucidate the pathogenesis of disorders of rhythm in myocardial infarction. The role of bradycardia during the first few hours has been discussed, and the use of atropine has been criticised. Some light has been thrown on the importance of the Purkinje network in the infarcted zone. Some new concepts have been applied to the disturbances in exchange across membranes. The authors present the results of a series of experiments on the action of lactate and that of acidosis. The latter is responsible for upturns in the descending phase of the action potential these can cause re-excitation, and give rise to responses containing 2, 3 and even more propagated action potentials.
在过去几年中，已经开展了许多实验工作，试图阐明心肌梗死时节律紊乱的发病机制。人们讨论了最初几小时内心动过缓的作用，并且对阿托品的使用提出了批评。关于梗死区域浦肯野网络的重要性已有所了解。一些新的概念已应用于跨膜交换紊乱。作者展示了一系列关于乳酸作用和酸中毒作用的实验结果。酸中毒是动作电位下降期出现上升的原因，这些上升可导致再次兴奋，并引发包含2个、3个甚至更多传播性动作电位的反应。
