Shore D L, Sandler D P, Davey F R, McIntyre O R, Bloomfield C D
Westat, Inc., Durham, North Carolina.
Arch Environ Health. 1993 Nov-Dec;48(6):414-20. doi: 10.1080/00039896.1993.10545963.
Possible associations between location of residence and acute leukemia risk were investigated in a study of 610 newly diagnosed patients, aged 18-79 y, and 618 population controls. There was an association between ever living within 5 miles (8 km) of an industrial plant and leukemia risk, with adjusted odds ratios (ORs) of 1.4 (95% confidence interval [95% CI] = 1.0-1.9) for all acute leukemias combined, 1.4 (95% CI = 1.0-2.0) for acute myeloid leukemia, and 1.7 (95% CI = 1.0-2.7) for acute lymphocytic leukemia. Odds ratios increased with decreasing distance from industrial sites, but a gradient with duration of residence was seen only among those less than age 60 who had lived within a mile of any industry. Suggestive associations were also observed for residence near specific industries, but the number of individuals living near any one industry was small.
在一项针对610名年龄在18 - 79岁的新诊断患者和618名人群对照的研究中，调查了居住地点与急性白血病风险之间可能存在的关联。曾居住在工厂方圆5英里（8公里）范围内与白血病风险存在关联，所有急性白血病合并后的校正比值比（OR）为1.4（95%置信区间[95%CI]=1.0 - 1.9），急性髓系白血病为1.4（95%CI = 1.0 - 2.0），急性淋巴细胞白血病为1.7（95%CI = 1.0 - 2.7）。比值比随着与工业场所距离的缩短而增加，但仅在居住在任何行业方圆1英里内且年龄小于60岁的人群中观察到居住时间的梯度变化。在特定行业附近居住也观察到了提示性关联，但居住在任何一个行业附近的个体数量较少。
