Acar J, Carpentier A, Chomette G, Lelguen C, Geschwind H, Starkman S
Arch Mal Coeur Vaiss. 1976 Sep;69(9):929-34.
From a series of 10 patients undergoing surgery with a homograft, two cases are reported in which stenosis of the graft occurred, one in the mitral and the other in the aortic position. The macroscopical appearances of the lesions showed sclerosis and calcification. In the case where histological material was available, there were marked changes in the collagen and elastin, disseminated calcified deposits in the valve, and inflammatory cellular changes over the surface, with a tendency to penetrations into the substance of the valve. One of the factors leading to these graft disorders is the type of chemical treatment which the valve undergoes; a combination of glutaraldehyde solution and oxidation using sodium metaperiodate would appear to be unsuitable in this respect. Emphasis is laid on the very particular clinical features of these two cases (stenosis and valvular incompetence), and on the difficulties in diagnosis of this condition.
在一组接受同种异体移植手术的10例患者中，报告了2例移植物发生狭窄的病例，1例发生在二尖瓣位，另1例发生在主动脉瓣位。病变的宏观表现为硬化和钙化。在有组织学材料的病例中，胶原和弹性蛋白有明显变化，瓣膜中有散在的钙化沉积物，表面有炎性细胞变化，并有向瓣膜实质内浸润的倾向。导致这些移植物病变的因素之一是瓣膜所接受的化学处理类型；在这方面，戊二醛溶液和高碘酸钠氧化的联合使用似乎不合适。文中强调了这两例病例非常特殊的临床特征（狭窄和瓣膜关闭不全）以及这种疾病诊断中的困难。
