Iwasaki E, Yamaura M, Baba M
Department of Pediatrics, Doai Memorial Hospital.
Arerugi. 1993 Aug;42(8):907-13.
Disodium cromoglycate (DSCG) is easily absorbed from the airways and lungs, and is excreted unchanged in the urine and bile. Therefore it is possible to estimate the dose of DSCG deposited in the airways and lungs based upon urinary excretion. The urinary concentration of DSCG was measured by the HPLC method in 78 asthmatic children aged 0 to 16 years after they had inhaled 20 mg nebulizer solutions with facemasks. Jet-type nebulizers were used. The mean urinary excretion of DSCG in the patients aged 0, 1, 2 and 3 years from 4-hour urinary collection represented 0.204%, 0.231%, 0.593%, 0.790%, respectively, of the dose administered. In the patients aged 3, 4, 5-6, 7-9 and 10-16 years, from 24-hour urinary collection, the figures were 0.625%, 0.895, 0.855, 1.176%, 1.070%, respectively. The mean dose deposited in the airways and lungs of the age groups 0-1, 2, 3, 4-6, 7-9, and 10-16 years represented approximately 0.5%, 1.4%, 1.4-1.8%, 2.0%, 2.7%, 2.4%, respectively, of the dose administered. Although there was a wide range in the total amount of DSCG deposited in the airways and lungs of asthmatic children, these data seem to provide a useful guide to standardizing the dosing in inhalation therapy.
色甘酸钠（DSCG）易于从气道和肺吸收，并以原形经尿液和胆汁排泄。因此，可根据尿排泄量估算沉积在气道和肺中的DSCG剂量。采用高效液相色谱法（HPLC）测定了78名0至16岁哮喘儿童面罩吸入20mg雾化溶液后的尿中DSCG浓度。使用的是喷射式雾化器。0、1、2和3岁患者4小时尿样中DSCG的平均尿排泄量分别占给药剂量的0.204%、0.231%、0.593%、0.790%。3、4、5 - 6、7 - 9和10 - 16岁患者24小时尿样中的相应数据分别为0.625%、0.895、0.855、1.176%、1.070%。0 - 1、2、3、4 - 6、7 - 9和10 - 16岁年龄组沉积在气道和肺中的平均剂量分别约占给药剂量的0.5%、1.4%、1.4 - 1.8%、2.0%、2.7%、2.4%。尽管哮喘儿童气道和肺中沉积的DSCG总量范围较宽，但这些数据似乎为吸入治疗的剂量标准化提供了有用的指导。
