Bjorkman D J, Boschert M, Tolman K G, Clegg D O, Ward J R
Division of Gastroenterology, University of Utah College of Medicine, Salt Lake City.
Arthritis Rheum. 1993 Dec;36(12):1697-701. doi: 10.1002/art.1780361208.
To evaluate the progression of hepatic fibrosis in patients with rheumatoid arthritis (RA) treated with methotrexate (MTX).
Fifteen patients receiving MTX for RA were prospectively studied by electron microscopic analysis of biopsy specimens.
Five of the 15 patients had evidence of increased hepatic collagen after 2 years of MTX therapy.
Hepatic fibrosis may progress in a subgroup of RA patients treated with MTX.
评估接受甲氨蝶呤（MTX）治疗的类风湿关节炎（RA）患者肝纤维化的进展情况。
对15例接受MTX治疗RA的患者进行前瞻性研究，通过对活检标本进行电子显微镜分析。
15例患者中有5例在接受MTX治疗2年后出现肝脏胶原增加的证据。
接受MTX治疗的RA患者亚组中可能会出现肝纤维化进展。
