Dowd J E, Lipsky P E
Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center, Dallas 75235-8844.
Arthritis Rheum. 1993 Dec;36(12):1735-8. doi: 10.1002/art.1780361213.
We describe a 21-year-old Hispanic woman who presented with hypokalemic paralysis as the initial manifestation of Sjögren's syndrome (SS). Our review of the English literature revealed 12 previously reported cases of SS and renal tubular acidosis (RTA). Paralysis often preceded the sicca complex in those patients. Renal function in the patients with hypokalemic paralysis was reduced compared with that in patients who had primary SS and RTA but no history of hypokalemic paralysis (P < 0.002). Hypokalemic periodic paralysis is a rare manifestation of SS. It is seen more often in patients with primary SS, may precede the classic sicca complex, and may serve as a clinical marker for more severe renal disease in patients who have primary SS and RTA.
我们报告了一名21岁的西班牙裔女性，她以低钾性麻痹作为干燥综合征（SS）的初始表现。我们对英文文献的回顾发现了12例先前报道的SS合并肾小管酸中毒（RTA）病例。在这些患者中，麻痹通常先于干燥综合征出现。与原发性SS和RTA但无低钾性麻痹病史的患者相比，低钾性麻痹患者的肾功能有所下降（P < 0.002）。低钾性周期性麻痹是SS的一种罕见表现。它在原发性SS患者中更常见，可能先于典型的干燥综合征出现，并且可能作为原发性SS和RTA患者更严重肾脏疾病的临床标志物。
