Graves C J, Edwards C, Marks R
Department of Dermatology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
Br J Dermatol. 1993 Nov;129(5):558-62. doi: 10.1111/j.1365-2133.1993.tb00484.x.
In this study, the role of mechanical trauma to skin in industrial dermatitis is considered. The percussive component of mechanical trauma to skin is investigated by modelling it, using an oscillating device which can supply a range of percussive trauma doses. The instrument is electronically controlled, and contains sensors which monitor the force and displacement throughout each impact. From this information, a value proportional to the dose delivered to the skin is calculated and used, rather than the driving power of the percussor. The rate of dose is also controlled. In this study, doses were delivered at a frequency of 7 Hz. Eight volunteers were given regimens of percussive trauma at regular intervals over a 5-day period. Half the group received a dose of 4 mJ/cm2 per impact, the other half received double this dose. The skin response was evaluated using non-invasive measurements of transepidermal water loss, skin thickness, and erythema. The results demonstrate that erythema, skin thickness and transepidermal water loss are all increased after mechanical challenge--erythema and water loss by amounts dependent upon the trauma dose applied. The transepidermal water loss results indicate that for the subjects used in our study, there was a trauma threshold reached after a cumulative dose of greater than 250 J/cm2.
在本研究中，探讨了机械性皮肤创伤在职业性皮炎中的作用。通过使用一种能够提供一系列冲击创伤剂量的振荡装置进行模拟，研究了机械性皮肤创伤的冲击成分。该仪器由电子控制，包含传感器，可在每次冲击过程中监测力和位移。根据这些信息，计算并使用与施加到皮肤上的剂量成比例的值，而不是冲击器的驱动功率。剂量率也受到控制。在本研究中，剂量以7Hz的频率施加。八名志愿者在5天内定期接受冲击创伤方案。该组一半人每次冲击接受4mJ/cm²的剂量，另一半人接受双倍剂量。使用经皮水分流失、皮肤厚度和红斑的非侵入性测量方法评估皮肤反应。结果表明，机械性刺激后红斑、皮肤厚度和经皮水分流失均增加——红斑和水分流失的量取决于施加的创伤剂量。经皮水分流失结果表明，对于我们研究中使用的受试者，累积剂量大于250J/cm²后达到创伤阈值。
